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The story

Since its creation in 1987 by Christian Diehl, a pharmacist based in Bourg-en-Bresse, France, Isispharma Laboratory has focused its research on the natural balance – homeostasis – and the imbalances of the skin to develop innovative and effective solutions to help each patient suffering from skin problems regain healthy skin.


Pioneering in the treatment of specific skin disorders such as hyperpigmentation, rosacea, and vitiligo, Isispharma quickly became renowned among dermatologists and patients for the efficacy of its solutions.

Since it was acquired in 2002 by the DEWAVRIN Group, a family-owned business specialized in the health and beauty industry, the laboratory has accelerated its international expansion while continuing to develop innovative and effective solutions.

Today, Isispharma’s skincare products are recommended by over 14,000 dermatologists in 80 countries.

  • 1987

    Creation of Isis Laboratory by Christian Diehl in Bourg en Bresse, France.
  • 1987 – 2002

    Development of Unitone, Ruboril and Vitiskin formulas and export to various countries.
  • 2002

    Laboratory is acquired by the DEWAVRIN Group, a family-owned business specialized in the health and beauty industry.
  • 2002-2010

    Export development speeds up.
  • 2010

    Creation of Neotone range, new generation of skincare for dark spots.
  • 2014

    Isispharma expands and moves to its new headquarters in the center of Lyon, France.
  • 2015

    Release of Metroruboril AZ, first skincare product specialized in severe redness.
  • 2016

    Collaboration with the French National Center for Scientific Research (CNRS) in Lyon to improve knowledge of skin homeostasis.
  • 2018

    Creation of Xerolan spray for severe and localized xerosis.
  • 2019

    Publication in JEADV (Major dermatology journal) of the clinical study Neotone vs 4% hydroquinone.